VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Hamster

Scientific Name: Mesocricetus auratus

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Euarchontoglires-> Glires-> Rodentia-> Myomorpha-> Muroidea-> Cricetidae

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Hepacivirus C

Family: Flaviviridae

Receptor: LDLR

Receptor LDLR information

Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_0015 2021.04 10X Genomics Heart Normal 3063 Link
Vthunter_0016 2021.04 10X Genomics Kidney Normal 7180 Link
Vthunter_0017 2021.04 10X Genomics Liver Normal 18383 Link
Vthunter_0018 2021.04 10X Genomics Lung Normal 1695 Link
Vthunter_110072 2019.12 MARS-seq TotalBrain Normal 768 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of LDLR in human tissues   [NCBI]

Expression: Ubiquitous expression in adrenal (RPKM 29.0), lung (RPKM 28.5) and 25 other tissues?

Protein expression of LDLR in human tissues   [Proteinatlas]